Molecular biology of the kallikrein-kinin system: from structure to function
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چکیده
منابع مشابه
Molecular biology of the kallikrein-kinin system: from structure to function.
The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a matter of controversy. The use of different experimental set-ups in concert with the development of potent and specific inhibitors and antagonist...
متن کاملThe renal kallikrein-kinin system.
THE KIDNEY contains several hormonal systems—kallikrein-kinin, renin-angiotensin, prostaglandin—which serve as renal self-regulatory mechanisms and may have extrarenal effects as well. Although the functions of the kallikrein-kinin system are incompletely defined, there is evidence that it may regulate renal blood flow, modulate tubular salt and water transport, and participate in the pathogene...
متن کاملKallikrein-kinin system in neovascularization.
Kinin System in Neovascularization − Kallikrein Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2009 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/ATVBAHA.109.184549 2009;29:617-619 Arterioscler Thromb Vasc Biol. http://atvb.a...
متن کاملFifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology.
Thromb Haemost 2007; 98: 77–83 For forty years my laboratory has been studying the kallikrein-kininogen-kinin system (KKS). I was challenged by my mentor Dr. Sol Sherry in whose laboratory I was completing my postdoctoral fellowship in 1966–1967 to find out what major plasma esterase was being activated by exposure of plasma to glass beads. Although both factors XII and XI were candidates, neit...
متن کاملThe kallikrein-kinin system in diabetic nephropathy
Diabetic nephropathy is the major cause of end-stage renal disease worldwide. Although the renin-angiotensin system has been implicated in the pathogenesis of diabetic nephropathy, angiotensin I-converting enzyme inhibitors have a beneficial effect on diabetic nephropathy independently of their effects on blood pressure and plasma angiotensin II levels. This suggests that the kallikrein-kinin s...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 1998
ISSN: 0100-879X
DOI: 10.1590/s0100-879x1998000900013